Dr Mohammad Ali, MD (Medicine) moalajat
Rampur karkhana, Deoria (UP)
Dyslipidemia is elevation of plasma cholesterol, triglycerides (TGs), or both, or a low high-density lipoprotein level that contributes to the development of atherosclerosis. Causes may be primary (genetic) or secondary. Diagnosis is by measuring plasma levels of total cholesterol, TGs, and individual lipoproteins. In Unani system of medicine it is called fasade tadassum fil dam it is due to Amraze Istahala (metabolic disorder).Dyslipidemias were traditionally classified by patterns of elevation in lipids and lipoproteins .
A more practical system categorizes dyslipidemias as primary or secondary and characterizes them by increases in cholesterol only (pure or isolated hypercholesterolemia), increases in TGs only (pure or isolated hypertriglyceridemia), or increases in both cholesterol and TGs (mixed or combined hyperlipidemias.
Etiology
Primary (genetic) causes and secondary (lifestyle and other) causes contribute to dyslipidemias in varying degrees. For example, in familial combined hyperlipidemia, expression may occur only in the presence of significant secondary causes
Primary causes: Primary causes are single or multiple gene mutations that result in either overproduction or defective clearance of TG and LDL cholesterol, or in underproduction or excessive clearance of HDL.Primary disorders, the most common cause of dyslipidemia in children, do not cause a large percentage of cases in adults.
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