What is the infectious disease that killed the most number of humans in history?

Inver Grove Heights

Is it the Black Death/Bubonic Plague?



Kensal

Spanish Flu killed between 50-100mil people. Bubonic plague killed between 75-200mil people. So could be either. It wouldn't be a huge shock if the historians of the time overstated the effects of the plague to make themselves seem more important.



Scott Township

many people consider Life to be the most infectious disease. And everyone dies from that.



Twin Valley

My bet is smallpox or malaria.



Coyanosa

Smallpox. Half a billion dead in the 20th century alone. It's only two rivals are malaria and tuberculosis.



Port Deposit

It's the bubonic plague/Black Death, easily



Elwood

Smallpox is considered to have killed the most people in history. The black plague killed over 25 million in the medieval ages, a third of Europe's population. http://www. qualityhealth. com/health-life…